24 Active Ingredients in BrainAlert
- Bacopa Monniera
- Folic Acid
- Ginkgo Biloba
- Gotu Kola
- Huperzine A
- N-Acetyl Tyrosine
- Panax Ginseng
- R-Alpha Lipoic Acid
- Rhodiola Rosea
- Vitamin B1 Thiamine
- Vitamin B2 Riboflavin
- Vitamin B3 Niacinamide
- Vitamin B5 Pantothenic Acid
- Vitamin B6 Pyridoxine
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- Some participants who use acetyl-l-carnitine have reported being more
mentally sharp, focused, alert and in a better mood.
- Studies have shown acetyl-l-carnitine to...
- help facilitate regeneration of nerves. 1
- reduce the formation of a cell-clogging pigment called lipfuscin.
- work synergistically with CoQ10 and alpha lipoic acid creating an
anti-aging effect which helps to maintain mitochondria
- provide significant improvements in cognitive function for people with
mild cognitive impairment after 45 days of use. 5
- provide significant improvement in memory, mood, and response to
stress for elderly people after 90 days of use and the effects
lasted at least 30 days after the trial had ended. 6
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- Users of bacopa monniera have reported increased
relaxation, academic performance, short term and long term
memory, and concentration in stressful situations.
- The use of bacopa for memory enhancement can be traced
back over 2000 years ago when bacopa was cited for its memory
enhancing attributes in the Indian Vedic texts Athar-Ved Samhita
in 800 B.C.. 11
- A 1969 study showed that animals who were given bacopa
had increased learning abilities and memory enhancement.
- In 1996, Scientists from India's Central Drug Research Institute reported that bacopa
reduces the time to learn a specific task from ten days to six
days (a 40% reduction in time).
- One study reported that when bacopa was given to a
group of children, the children improved their speed and
accuracy on maze problems. 14
- Bacopa was reported to improve IQ scores in 10 to 13
year olds of average intelligence during a 9 month period of
- Findings suggest that Bacopa may improve higher order
cognitive processes such as learning and memory.
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is a patented extract obtained from black pepper fruits of
southern India .
- Bioperine® was clinically tested in the USA and has been found to
significantly enhance the absorption of many nutrients. 17
- Many nutritionists are beginning to agree that better
nutrition relies not just on what people eat, but how well they
absorb what they eat.
- Some studies show that
Bioperine® can increase
absorption of CoQ10 by approximately 30%, while other trials
show a 2000% absorption increase (BrainAlert contains CoQ10). 18
- Bioperine has been used with the following ingredients
to increase absorption:
herbal extracts (ashwagandha, capsaicin, curcumin, boswellia
serrata, and ginkgo biloba), amino acids (isoleucine, leucine,
lysine, methionine, phenylalanine, threonine, tryptophan, and
valine), water-soluble vitamins (folic acid, niacin, vitamin B1,
B2, B6, B12, and C), fat-soluble vitamins (vitamin A, D, E, and
K) and minerals (calcium, chromium copper, iodine, iron,
magnesium, manganese, potassium, vanadium, and zinc).
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- A study examining 349 patients, 64 years and older from 6 regions in Italy who had memory complaints, showed that participants who received Citicoline had significantly higher memory scores, as shown on the Mini–Mental State Examination (MMSE), with treatment of up to 9 months compared with their counterparts who did not receive Citicholine.
- Supports increased levels of nuerotransmitters, such as dopamine and norepinephrine.
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- Many people supplement their diet with CoQ10 to increase energy, to support immune system function, and for its antioxidant properties.
- CoQ10 is found naturally in fish and animal meats.
- CoQ10 is found naturally in the body, with the highest concentrations in the kidney, liver, and heart.
- CoQ10 levels begin to decline after approximately 30 years of age. 27
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- DMAE was used to help ADD children in the 1980's, with studies showing improvement in memory, concentration, and the ability to focus. 28,29
- Some individuals taking DMAE as a supplement report a noticeable boost in concentration, memory, improved focus, sleep pattern, and mental clarity.
- Some participants who take DMAE report falling asleep easier, have more lucid dreams, less fatigue in the day, deeper sleep, and needing less sleep at night. 30
- A study consisting of 83 boys and 25 girls found improved scholastic ability, lengthened attention span, decreased hyperactivity, and decreased irritability among two-thirds of the boys and three-fourths of the girls. 31
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acid is also known as folate and vitamin B9.
acid is one of eight water-soluble complex B vitamins that are
essential in the breakdown of fats and proteins.
acid is also known to play an important role in mental and
acid aids in the production of DNA and RNA.
have shown folic acid to promote memory retention. 34
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biloba is an herbal extract from the leaves of the ginkgo tree
(the world's oldest living tree) and has been used
therapeutically in China for thousands of years.
- For the past five years ginkgo biloba has been the top-selling
herbal dietary supplement in the United States. 35
have shown Ginkgo Biloba to...
to the improvement of cognitive performance and function. 36,39
improve memory. 37
- Pooled results from 33 studies show that the recommended dose of ginkgo
biloba (<200mg/day) can significantly improve emotional
health and mood, cognition, and daily activities. 38
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thousands of years gotu kola has been used as a medicinal herb
in China, India, and Indonesia.
kola is a tender plant with long stems and small grey-green
leaves, and is typically found in high marshy areas of
South Africa, Madagascar, India, and Pakistan.
kola is considered to be a "miracle elixir of life" in China.
gotu kola has been used to treat anxiety (1)(2), though it is
also associated with learning and recollection enhancement.
have tested the herb in relation to startle response, since
evidence suggests that easy startling is associated with
measuring eye blinks in response to sudden loud noises, Gotu
Kola significantly reduced startle response. 41
- A 1992 study claimed that gotu kola improved the cognitive
abilities of rats. 42
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A is an extract from a club moss (Huperzia Serrata) and has been
used for centuries in China.
primary purpose of huperzine A is to prevent the breakdown of
acetylcholine. Acetylcholine is vital to the nervous system for
transmitting information between cells. 43
have shown Huperzine A to...
- promote memory and learning. 44
- be more effective and selective than tacrine, a pharmaceutical
drug, at inhibiting cholinesterase. 45-60
protect nerve cells from damage. 61-64
A appears to bind more tightly and specifically to
acetylcholinesterase than the other acetylcholinesterase
inhibitors. It is as if this natural substance were ingeniously
designed to fit into the exact spot in acetylcholinesterase
where it will do the most good." Prof. Joel Sussman
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- Carnosine significantly increases the endurance,
contractility, and minimizes lactic acid build up of muscles.
- Carnosine is a metal chelator, meaning it helps remove
metals from the body.
- Carnosine levels decrease with age.
From age 10 to 70, muscle levels decline 63%, which may
be linked to the decrease of carnosine levels.
- Research has shown that carnosine rejuvenates cells as
they approach advanced ages. 20
- A 1999 Russian study showed that carnosine extended
the life span of treated mice by an average of 20% compared to
non-treated mice. The
mice were twice as likely to reach old age as untreated mice.
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is a coenzyme form of vitamin B12 (cyanocobalamin).
B12 helps methylation reactions and immune system
indicates that Methylcobalamin has some effects not shared by
regular vitamin B12.
have shown Methylcobalamin to...
brain cells against glutamate toxicity.65
amount of time people sleep while improving the quality of
sleep so that the individuals awake feeling more refreshed.67
help regenerate nerves. 68
regenerate damaged brain axons.69
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Tyrosine is an acetylated derivative of the essential amino acid
helps to improve the metabolic effect of L-Tyrosine.
is the precursor of several neurotransmitters in the brain
including epinephrine, norepinephrine, and dopamine.
have shown Tyrosine to...
learning and alertness.72
mental and physical fatigue.
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Ginseng is one of the most popular and highly researched forms
root of the ginseng plant has been prescribed in
for hundreds of years to improve energy levels.
benefits of ginseng have been written about as far back as the
Sui Dynasty of China (580 - 601 A.D.).
is one of the most popular selling herbs around the world.
have shown panax ginseng to...
physical and mental performance.74,75
resistance to stress factors.74,75
reactions and abstract thinking.
attention, processing, auditory reaction time, mental health,
and social functioning.77,78
secondary memory performance, speed of memory tasks, and
accuracy of attention tasks.79
immune system function. 80,81
comparative, randomized, and double-blind government study
indicated that ginseng is "a promising dietary supplement"
in regards to an increase in quality of life.
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- Double-blind studies have found this ingredient to help improve mental function in people with age-related memory loss.
- It has also been proposed for enhancing mental function in young people.
R-Alpha Lipoic Acid
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Acid (ALA) may be a more potent antioxidant than classic
antioxidants, such as Vitamins E and C.
ALA was first isolated in 1953, and is sometimes referred to as
"universal antioxidant" because it is soluble in both fat
and water. 84
have shown Alpha-Lipoic acid to...
other antioxidants back to their active states, including
CoQ10, and vitamins C and E.85-87
improve activity, energy levels, and cognitive functions of
old rats when combined with acetyl-l-carnitine.
88-90 (BrainAlert contains acetyl-l-carnitine)
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rosea is a perennial plant that grows in the arctic areas of
Europe and Russia
rosea has long been used in the traditional medicines of
and Scandinavia 91
and has been extensively researched in
for the last several decades.
than 170 studies have been published on Rhodiola Rosea since the
2004 study showed rhodiola rosea to improve endurance-exercise
capacity in young and healthy individuals.
2003 study showed rhodiola rosea to provide a definite decrease
in mental fatigue. 93
have shown rhodiola rosea to...
- stimulate the body, decrease fatigue, and decrease
- significantly decrease the percent of errors made in a
proof-reading test. 101,102
- increase intellectual capacity more than siberian
ginseng (14) 103
1970, a Russian study claimed that rhodiola rosea
supplementation increased the quality and amount of work for 27
healthy students, physicians, and scientists.104
20 day study of 60 Indian medical students in 2000 showed that
while studying for final exams, those who took a Rhodiola Rosea
extract yielded significant improvements in their physical
fitness, general well-being, and final exam grades.
double-blind placebo-controlled study of 60 high school students
in 2000, showed that Rhodiola Rosea supplementation increased
work capacity, coordination, and feelings of well-being, while
simultaneously decreasing fatigue and stress.
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is also known as betaine and its functions are similar to folic
acid and vitamin B12.
was originally discovered in the 1950's to be beneficial to
the heart, but soon after some users indicated improvements to
their energy, alertness, and mood.
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is a semi-synthetic derivative of a periwinkle plant extract.
increases blood circulation and metabolism in the brain.
100 clinical studies have revealed vinpocetine to be safe and
have shown vinpocetine to...
improve attention, concentration, and memory. 115
increase cerebral blood flow.
114 Due to this increase of blood flow to the
brain, vinpocetine works synergistically with other cognitive
- help reduce platelet aggregation while improving
deformation resistance of red blood cells.
Vitamin B1 Thiamine
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1926 vitamin B1, also known as thiamine, was the
first vitamin to be isolated in pure form.
is vital to the metabolism of carbohydrates and amino acids.
in B vitamins can lead to fatigue and poor mental functioning.
recent years there has been a decrease in B vitamins intake
due to the increased consumption of refined foods.
have shown Vitamin B1 to...
cognitive benefits, including faster reaction times,
clear-headedness, and increased concentration.
mood and energy. 113
Vitamin B2 Riboflavin
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- Vitamin B2 is found in meats, eggs, nuts, milk, and
green leafy vegetables.
- Vitamin B2 is also called riboflavin and is one of
eight water soluble B vitamins.
- Some authorities clam that vitamin B2 deficiency is
the most common nutrient deficiency in the
- Vitamin B2 plays a role in enzyme function, amino acid
synthesis, and energy production.
Vitamin B3 Niacinamide
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was discovered in 1911.
and niacin are both vitamin B3, but niacinamide has different
pharmological activities than niacin.
is easily absorbed by the gastrointestinal tract.
works in conjunction with vitamin B1 and vitamin B2 to convert
carbohydrates into energy.
have shown niacinamide to produce
an anti-anxiety effect. 124
Vitamin B5 Pantothenic Acid
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acid was first identified in 1933.
concentrations of pantotheic acid can be found in salmon,
brewer's yeast, soybeans, duck, broccoli, and corn.
acid works together with vitamins B1, B2, and B3 to create
energy in the body.
acid supports adrenal function in high stress situations.
acid is easily absorbed by the gastrointestinal tract.
study showed that diets supplemented with 12.5mg of pantothenic
acid decreased symptoms of osteoarthritis.
users of pantothenic acid report improved alertness, energy, and
Vitamin B6 Pyridoxine
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was first discovered in 1934.
a million people supplement their diet with pyridoxine to help
alleviate stress and increase energy.
is found in some cereals, beans, meats, fruits, and vegetables.
study involving 76 elderly males showed pyridoxine to help
improve long-term memory. 133
supports the manufacturing of enzymes, hormones, red blood
cells, and neurotransmitters.
is needed in order for the human body to produce serotonin.
130 Serotonin is a neurotransmitter that controls
appetite, sleep patterns, and mood.
1. Fernandez E, Pallini R, Lauretti L, La Marca F, Sccgna A, Rossi GF, Center for Research in Regeneration of the Nervous System, Catholic University Medical School, Rome, Italy. Motonuclear changes after cranial nerve injury and regeneration. Arch Ital Biol (Italy) 1997 Sep;135(4):343-51.
2. Amenta F, Ferrante F, Lucreziotti R, Ricci A, Ramacci MT, Dipartimento di Scienze Neurologiche, Universita La Sapienza, Rome, Italy. Reduced lipofuscin accumulation in senescent rat brain by long-term acetyl-L-carnitine treatment. Arch Gerontol Geriatr 1989 Sep-Oct;9(2):147-53.
3. Di Donato S, Frerman FE, Rimoldi M, Rinaldo P, Taroni F, Wiesmann UN. Systemic carnitine deficiency due to lack of electron transfer flavoprotein: ubiquinone oxidoreductase. Neurology 1986 Jul;36(7):957-63.
4. Schonheit K, Gille L, Nohl H, Institute of Pharmacology and Toxicology, Veterinary University of Vienna, Austria. Effect of alpha-lipoic acid and dihydrolipoic acid on ischemia/reperfusion injury of the heart and heart mitochondria. Biochim Biophys Acta 1995 Jun 9;1271(2-3):335-42.
5. Salvioli G, Neri M. L-acetylcarnitine treatment of mental decline in the elderly. Drugs Exp Clin Res 1994;20(4):169-76.
6. Salvioli G, Neri M. L-acetylcarnitine treatment of mental decline in the elderly. Drugs Exp Clin Res 1994;20(4):169-76.
7. Kuboyama T, Tohda C, Zhao J, Nakamura N, Hattori M, Komatsu K. Axon- or dendrite-predominant outgrowth induced by constituents from Ashwagandha. Neuroreport. 2002 Oct 7;13(14):1715-20.
8. Tohda C, Kuboyama T, Komatsu K. Dendrite extension by methanol extract of Ashwagandha (roots of Withania somnifera) in SK-N-SH cells. Neuroreport. 2000 Jun 26;11(9):1981-5.
9. Bhattacharya A, Ghosal S, Bhattacharya SK. Anti-oxidant effect of Withania somnifera glycowithanolides in chronic footshock stress-induced perturbations of oxidative free radical scavenging enzymes and lipid peroxidation in rat frontal cortex and striatum. J Ethnopharmacol. 2001 Jan;74(1):1-6.
10. Schliebs R, Liebmann A, Bhattacharya SK, Kumar A, Ghosal S, Bigl V. Systemic administration of defined extracts from Withania somnifera (Indian Ginseng) and Shilajit differentially affects cholinergic but not glutamatergic and GABAergic markers in rat brain. Neurochem Int. 1997 Feb;30(2):181-90.
11. Sekar P. Vedic clues to memory enhancer. The Hindu, March 21, 1996.
12. Ganguly DK, Malhotra CL. Some behavioural effects of an active fraction from Herpestis monniera Linn. (Brahmi). Indian J Physiol Pharmacol 1969 Jul;13(3):163-7.
13. Central Drug Research Institute, Lucknow, India. NLAC-Newsletter, Spring 1996.
14. Sharma R, Chaturvedi C, Tewari PV. Efficacy of Bacopa monierra in revitalizing intellectual functions in children. J Rees Edu Ind Med 1987:1-12.
15. Abhang R. Study to evaluate the effect of a micro (Suksma) medicine derived from Brahmi (Herpestis monniera) on students of average intelligence.
J Res Ayur Siddha 1993 14(1-2):10-21
16. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl) 2001 Aug;156(4):481-4
17. Velpandian, T., Jasuja, R., Bhardwaj, R.K., Jaiswal, J., & Gupta, S.K. (2001). Piperine in food: interference in the pharmacokinetics of phenytoin. European Journal of Drug Metabolism and Pharmacokinetics, 26, 241-247
18. Badmaev, V. V., Majeed, M., & Prakash, L. (2000). Piperine derived from black pepper increases the plasma levels of coenzyme q10 following oral supplementation. Journal of Nutritional Biochemistry, 11, 109-113
19. Stuerenburg HJ, Kunze K. Concentrations of free carnosine (a putative membrane-protective antioxidant) in human muscle biopsies and rat muscles. Arch Gerontol Geriatr. 1999. 29: 107-113.
20. McFarland GA, Holliday R. Retardation of the senescence of cultured human diploid fibroblasts by carnosine. Exp Cell Res 1994; 212(2):167-75.
21. Yuneva MO, Bulygina ER, Gallant SC, et al. Effect of carnosine on age-induced changes in senescence-accelerated mice. J Anti-Aging Med. 1999; 2(4):337-42.
22. Boldyrev A, Song R, Lawrence D, et al. Carnosine protects against excitotoxic cell death independently of effects on reactive oxygen species. Neuroscience. 1999; 94(2):571-7.
23. Pyapili GK, Turner DA, Williams, CL. Prenatal dietary choline supplementation decreases the threshold for induction of long-term potentiation in young adult rats. J Neurophysiol. 1998; 79:1790-1796.
24. Buchman, A.L., et al. 2001. Verbal and visual memory improve after choline supplementation in long-term total parenteral nutrition: A pilot study. Journal of Parenteral and Enteral Nutrition 25(January-February):30.
25. Mortensen SA, Vadhanavikit S, Baandrup U, Folkers K. Long-term coenzyme Q10 therapy: a major advance in the management of resistant myocardial failure. Drug Exptl Clin Res 1985;11:581-93.
26. Soja AM, Mortensen SA. Treatment of chornic cardiac insufficiency with coenzyme Q10, results of meta-analysis in controlled clinical trials. Ugeskr Laeger 1997;159:7302
27. Shults CW, Oakes D, Kieburtz K, Beal F, Haas R, Plumb S, Juncos JL, Nutt J, Shoulson I, Carter J, Kompoliti K, Perlmutter JS, Reich S, Stern M, Watts RL, Kurlan R, Molho E, Harrison M, Lew M, and the Parkinson Study Group. "Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline." Archives of Neurology , October 2002, Vol. 59, No. 10, pp. 1541-1550.
28. Lewis JA, Young R. Deanol and methylphenidate in minimal brain dysfunction. Clin Pharmacol Ther. 1975;17:534-540.
29. Re O. 2-Dimethylaminoethanol (deanol): a brief review of its clinical efficacy and postulated mechanism of action. Curr Ther Res Clin Exp. 1974 Nov;16(11):1238-42.
30. Sergio W. Use of DMAE (2-dimethylaminoethanol) in the induction of lucid dreams. Med Hypotheses. 1988;26:255-257.
31. Pfeiffer CC, et al. Stimulant effect of 2-dimethyl-l-aminoethanol: possible precursor of brain acetylcholine. Science. 1957;126:610-611.
32. Pfeiffer CC. Parasympathetic neurohumors. Possible precursors and effect on behavior. International Review of Neurobiology. 1959:195-244.
33. New research reveals lifestyle habits linked to risk of getting Alzheimer's. 28 June. 2005. Alzheimer's Association. 8 Oct. 2005 < http://www.alz.org/preventionconference/pc2005/062805folate.asp >.
35. Blumenthal M. Herb sales down 15 percent in mainstream market. HerbalGram 2001;51:68.
36. Mix JA, Crews WD. A double-blind, placebo-controlled, randomized trial of Ginkgo biloba extract EGb 761 in a sample of cognitively intact older adults: neuropsychological findings. Human Psychopharmacol Clin Exp 2002;17:267-77.
37. Birks J, Grimley Evans J, Van Dongen M. Ginkgo Biloba for Cognitive Impairment and Dementia (Cochrane Review). In: The Cochrane Library, Issue 4, 2002. Oxford: Update Software.
38. Birks J, Grimley Evans J, Van Dongen M. Ginkgo Biloba for Cognitive Impairment and Dementia (Cochrane Review). In: The Cochrane Library, Issue 4, 2002. Oxford: Update Software
39. Mix JA, Crews WD. A double-blind, placebo-controlled, randomized trial of Ginkgo biloba extract EGb 761 in a sample of cognitively intact older adults: neuropsychological findings. Human Psychopharmacol Clin Exp 2002;17:267-77.
40. A Double-Blind, Placebo-Controlled Study on the Effects of Gotu Kola (Centella asiatica) on Acoustic Startle Response in Healthy Subjects.
Journal of Clinical Psychopharmacology. 20(6):680-684, December 2000.
Bradwejn, Jacques MD, FRCPC; Zhou, Yueping MD, PhD; Koszycki, Diana PhD ; Shlik, Jakov MD, PhD
41. Bradwejn J, Zhou Y, Koszycki D, et al. A double-blind, placebo-controlled study on the effects of Gotu Kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol. 2000;20:680-684.
42. Nalini K, Aroor AR, Karanth KS, et al. Effect of Centella asiatica fresh leaf aqueous extract on learning and memory and biogenic amine turnover in albino rats. Fitoterapia. 1992;63:232-237.
43. Ashani Y, Peggins JO 3d, Doctor BP. Mechanism of inhibition of cholinesterases by huperzine A. Biochem Biophys Res Commun 1992;184:719-26.
44. Sun QQ, et al. Huperzine-A capsules enhance memory and learning performance in 34 pairs of matched adolescent students. Chung Kuo Yao Li Hsueh Pao 1999 Jul;20(7):601-3.
45. Cheng DH, Ren H, Tang XC. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport. 1996;8:97-101.
46. Cheng DH, Tang XC. Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities. Pharmacol Biochem Behav. 1998;60:377-386.
47. Xiong ZQ, Tang XC. Effect of huperzine A, a novel acetylcholinesterase inhibitor, on radial maze performance in rats. Pharmacol Biochem Behav. 1995;51:415-419.
48. Zhi QX, Yi FH, XI CT. Huperzine A ameliorates the spatial working memory impairments induced by AF64A. Neuroreport. 1995;6:2221-2224.
49. Zhu XD, Giacobini E. Second generation cholinesterase inhibitors: effect of (L)-huperzine-A on cortical biogenic amines. J Neurosci Res. 1995;41:828-835.
50. Zhang GB, Wang MY, Zheng JQ, et al. Facilitation of cholinergic transmission by huperzine A in toad paravertebral ganglia in vitro [in Chinese; English abstract]. Zhongguo Yao Li Xue Bao. 1994;15:158-161.
51. Laganiere S, Corey J, Tang XC, et al. Acute and chronic studies with the anticholinesterase Huperzine A: effect on central nervous system cholinergic parameters. Neuropharmacology. 1991;30:763-768.
52. Tang XC, De Sarno P, Sugaya K, et al. Effect of huperzine A, a new cholinesterase inhibitor, on the central cholinergic system of the rat. J Neurosci Res. 1989;24:276-285.
53. Tang XC, Han YF, Chen XP, et al. Effects of huperzine A on learning and the retrieval process of discrimination performance in rats [in Chinese]. Zhongguo Yao Li Xue Bao. 1986;7:507-511.
54. Guan LC, Chen SS, Lu WH, et al. Effects of huperzine A on electroencephalography power spectrum in rabbits [in Chinese; English abstract]. Zhongguo Yao Li Xue Bao. 1989;10:496-500.
55. Lu WH, Shou J, Tang XC. Improving effect of huperzine A on discrimination performance in aged rats and adult rats with experimental cognitive impairment [in Chinese]. Zhongguo Yao Li Xue Bao. 1988;9:11-15.
56. Wang YE, Feng J, Lu WH. Pharmacokinetics of huperzine A in rats and mice [in Chinese]. Zhongguo Yao Li Xue Bao. 1988;9:193-196.
57. Wang YE, Yue DX, Tang XC. Anti-cholinesterase activity of huperzine A [in Chinese]. Zhongguo Yao Li Xue Bao. 1986;7:110-113.
58. Zhu XD, Tang XC. Improvement of impaired memory in mice by huperzine A and huperzine B [in Chinese]. Zhongguo Yao Li Xue Bao. 1988;9:492-497.
59. Zhu XD, Tang XC. Facilitatory effects of huperzine A and B on learning and memory of spatial discrimination in mice [in Chinese]. Yao Xue Xue Bao. 1987;22:812-817.
60. Yan XF, Lu WH, Lou WJ, et al. Effects of huperzine A and B on skeletal muscle and the electroencephalogram [in Chinese]. Zhongguo Yao Li Xue Bao. 1987;8:117-123.
61. Ved HS, Koenig ML, Dave JR, et al. Huperzine A, a potential therapeutic agent for dementia, reduces neuronal cell death caused by glutamate. Neuroreport. 1997;8:963-968.
62. Zhou J, Zhang HY, Tang XC. Huperzine A attenuates cognitive deficits and hippocampal neuronal damage after transient global ischemia in gerbils. Neurosci Lett. 2001;313:137-140.
63. Zhou J, Fu Y, Tang XC. Huperzine A protects rat pheochromocytoma cells against oxygen-glucose deprivation. Neuroreport. 2001;12:2073-2077.
64. Wang LM, Han YF, Tang XC. Huperzine A improves cognitive deficits caused by chronic cerebral hypoperfusion in rats. Eur J Pharmacol. 2000;398:65-72.
65. (1993 Sep.7; 7; 241 (1): 1-6), it was shown that ethylcobalamin protected against glutamate-, aspartate- and nitroprusside- induced neurotoxicity in rat cortical neurons
66. Clinical Therapeutics (1992 May; 14(3): 426-437)
67. Neuropharmacology (15: 456-464, 1996)
68. Journal of Neurological Science (1994 Apr. 122:140-143)
69. Farmakol Toksikol (1983 Nov; 46: 9-12) Nov 1983)
70. Neurological Disease: A Potential Breakthrough. Life Extension Magazine. Aug. 1998.
71. Gelenberg AJ, Gibson CJ, Wojcik JD. Neurotransmitter precursors for the treatment of depression. Psychopharmacol Bull 1982;18:7-18.
72. Banderet LE, Lieberman HR. Treatment with tyrosine a neurotransmitter precursor, reduces environmental stress in humans. Brain Res Bull 1989;22:759-62.
73. Lieberman, HR, Corkin S, Spring BJ, Wurtman RJ, and Growden JH. The effects of dietary neurotransmitter precursors on human behavior. Am J Clin Nutr 42: 366-370, 1985.
74. Mahady GB, Gyllenhall C, Fong HH, Farnsworth NR. Ginsengs: a review of safety and efficacy. Nutr Clin Care 2000;3:90-101.
75. Vogler BK, Pittler MH, Ernst E. The efficacy of ginseng. A systematic review of randomised clinical trials. Eur J Clin Pharmacol 1999;55:567-75.
76. Sorensen H, Sonne J. A double-masked study of the effects of ginseng on cognitive functions. Curr Ther Res Clin Exp 1996;57:959-68.
77. D'Angelo L, Grimaldi R, Caravaggi M, Marcoli M, Perucca E, Lecchini S, et al. A double-blind, placebo-controlled clinical study on the effect of a standardized ginseng extract on psychomotor performance in healthy volunteers. J Ethnopharmacol 1986;16:15-22.
78. Ellis JM, Reddy P. Effects of Panax ginseng on quality of life. Ann Pharmacother 2002;36:375-9.
79. Kennedy DO, Scholey AB, Wesnes KA. Modulation of cognition and mood following administration of single doses of Ginkgo biloba, ginseng, and a ginkgo/ginseng combination to healthy young adults. Physiol Behav 2002;75:739-51.
80. Scaglione F, Cattaneo G, Alessandria M, Cogo R. Efficacy and safety of the standardized Ginseng extract G115 for potentiating vaccination against the influenza syndrome and protection against the common cold [corrected]. Drugs Exp Clin Res 1996;22:65-72.
81. "Ginseng may reduce number, severity of colds". (Nov. 6, 2005). New Sunday Times, p. F19.
82. Yun TK, Choi SY. Non-organ specific cancer prevention of ginseng: a prospective study in Korea. Int J Epidemiol 1998;27:359-64.
83. Double-blind study of a multivitamin complex supplemented with ginseng extract. Caso Marasco A, Vargas Ruiz R, Salas Villagomez A, Begona Infante C. Universidad Nacional Autonoma (UNAM), Mexico. Drugs Exp Clin Res. 1996;22(6):323-9.
84. Kagan V, Khan S, Swanson C, et al. Antioxidant action of thioctic acid and dihydrolipoic acid. Free Radic Biol Med 1990;9S:15.
85. Kagan V, Serbinova E, Packer L. Antioxidant effects of ubiquinones in microsomes and mitochondria are mediated by tocopherol recycling. Biochem Biophys Res Commun 1990;169:851-7.
86. Lykkesfeldt J, Hagen TM, Vinarsky V, Ames BN. Age-associated decline in ascorbic acid concentration, recycling, and biosynthesis in rat hepatocytes-reversal with (R)-alpha-lipoic acid supplementation. FASEB J 1998;12:1183-9.
87. Scholich H, Murphy ME, Sies H. Antioxidant activity of dihydrolipoate against microsomal lipid peroxidation and its dependence on alpha-tocopherol. Biochem Biophys Acta 1989;1001:256-61.
88. Hagen, T.M., Liu, J., Lykkesfeldt, J., Wehr, C.M., Ingersoll, R.T., Vinarsky, V., Bartholomew, J.C., & Ames, B.N. (2002). Feeding acetyl-L-carnitine and lipoic acid to old rats significantly improves metabolic function while decreasing oxidative stress. Proceedings of the National Academy of Sciences, 99, 1870-1875
89. Liu, J., Head, E., Gharib, A.M., Yuan, W., Ingersoll, R.T., Hagen, T.M., Cotman, C.W., & Ames, B.N. (2002). Memory loss in old rats is associated with brain mitochondrial decay and RNA/DNA oxidation: Partial reversal by feeding acetyl-L-carnitine and/or R-alpha -lipoic acid Proceedings of the National Academy of Sciences, 99, 2356-2361
90. Liu, J., Killilea, D.W., & Ames, B.N. (2002). Age-associated mitochondrial oxidative decay: improvement of carnitine acetyltransferase substrate-binding affinity and activity in brain by feeding old rats acetyl-L- carnitine and/or R-alpha -lipoic acid. Proceedings of the National Academy of Sciences, 99, 1876-1881
91. Brown RP, Gerbarg PL, Ramazanov Z. Rhodiola rosea: a phytomedicinal overview. Herbalgram 2002;56:40-52.
92. Int J Sport Nutr Exerc Metab. 2004 Jun;14(3):298-307.
93. Phytomedicine. 2003 Mar;10(2-3):95-105.
94. Saratikov AS, Krasnov EA. Rhodiola rosea is a valuable medicinal plant (Golden Root). Tomsk, Russia: Tomsk State University Press; 1987.
95. Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue: a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine 2000;7(5):365-71.
96. Saratikov AS. Golden Root (Rhodiola rosea). Tomsk, Russia: Tomsk State University Press; 1974.
97. Spasov AA, Wikman GK, Mandrikov VB, Mironova IA, Neumoin VV. A double-blind, placebo-controlled pilot study of the stimulating and adaptogenic effect of Rhodiola rosea SHR-5 extract on the fatigue of students caused by stress during an examination period with a repeated low-dose regimen. Phytomedicine 2000;7(2):85-9.
98. Spasov AA, Mandrikov VB, Mironova IA. The effect of the preparation rhodiosin on the psychophysiological and physical adaptation of students to an academic load. Eksp Klin Farmakol 2000;63(1):76-8.
99. Furmanowa M, Oledzka H, Michalska M, Sokolnicka I, Radomska D. Chapter XXIII Rhodiola rosea L. (Roseroot): In vitro regeneration and the biological activity of roots.
100. Vol. 33. In: Bajaj YPS, editor. Biotechnology in Agriculture and Forestry. Vol. 33. Medicinal and aromatic plants. VIII. Berlin and Heidelberg, Germany: Springer-Verlag; 1995. p. 412-26.
101. Zatova MI, Krilov GV, Saratikov AS. Golden root: new stimulative and adaptogenic drug. Proceedings of Siberian Academy of Sciences. Biological and Medical Sciences. 1965;2:111-9.
102. Saratikov AS. Screening for natural central nervous system stimulants. In: Saratikov AS, editor. Stimulants of the Central Nervous System. Vol. 1. Tomsk, Russia: Tomsk State University Press; 1966 p. 3-23.
103. Darbinyan V, Kteyan A, Panossian A, Gabrielian E, Wikman G, Wagner H. Rhodiola rosea in stress induced fatigue: a double blind cross-over study of a standardized extract SHR-5 with a repeated low-dose regimen on the mental performance of healthy physicians during night duty. Phytomedicine 2000;7(5):365-71.
104. Krasik ED, Petrova KP, Rogulina GA, Shemetova LYa, Shuvayeva. New data on the therapy of asthenic conditions (clinical prospects for the use of Rhodiola extract). Proceedings of All-Russia Conference: Urgent Problems in Psychopharmacology 1970 May 26-29. Sverdlovsk, Russia: Sverdlovsk Press; 1970. p. 215-7.
105. Spasov AA, Mandrikov VB, Mironova IA. The effect of the preparation rhodiosin on the psychophysiological and physical adaptation of students to an academic load. Eksp Klin Farmakol 2000;63(1):76-8.
106. Selhub J. Homocysteine metabolism. Annu Rev Nutr 1999;19:217-46 [review].
107. Barak AJ, Tuma DJ. Betaine, metabolic by-product or vital methylating agent? Life Sci 1983;32:771-4 [review].
108. Barak AJ, Beckenhauer HC, Tuma DJ. Betaine, ethanol and the liver: a review. Alcohol. 1996;13:395-398.
109. Barak AJ, Beckenhauer HC, Junnila M, et al. Dietary betaine promotes generation of hepatic S-adenosylmethionine and protects the liver from ethanol-induced fatty infiltration. Alcohol Clin Exp Res. 1993;17:552-555.
110. Murakami T, Nagamura Y, Hirano K. The recovering effect of betaine on carbon tetrachloride-induced liver injury. J Nutr Sci Vitaminol. 1998;44:249-255.
111. Kanbak G, Inal M, Baycu C. Ethanol-induced hepatotoxicity and protective effect of betaine. Cell Biochem Funct. 2001;19:281-285.
112. Benton D, Griffiths R, Haller J. Thiamine supplementation mood and cognitive functioning. Psychopharmacology (Berl) 1997;129(1):66-71.
113. Benton D, Fordy J, Haller J. The impact of long-term vitamin supplementation on cognitive functioning. Psychopharmacology (Berl) 1995;117(3):298-305.
114. McDaniel MA, Maier SF, Einstein GO. "Brain-specific" nutrients: a memory cure? Nutrition 2003, Nov-Dec;19(11-12):957-75.
115. McDaniel MA, Maier SF, Einstein GO. "Brain-specific" nutrients: a memory cure? Nutrition 2003, Nov-Dec;19(11-12):957-75.
116. Coleston, D.M. and Hindmarh, I. Possible memory-enhancing properties or vinpocetine. Drug.Dev. Res. , 14:191-193 (1988)
117. Miyazaki , M. Correlation between cerebral circulation and intellectual impairment in patients with aging Brain, and the effect of vinpocetine on cerebral circulation. Drug. Dev. Res, 14:199-204 (1988).
118. Hayakawa, M. Effect of vinpocetine on red blood cells deformability in stroke patients. Arzneim-Forsch. 42:425-427 (1997).
119. Reference: European Journal of Neurology; 2004, Vol. 11, 475-7.
120. Elliott RB, Pilcher CC, Fergusson DM, et al. A population based strategy to prevent insulin-dependent diabetes using nicotinamide. J Pediatr Endocrinol Metab. 1996;9:501-509.
121. Pozzilli P, Visalli N, Signore A, et al. Double blind trial of nicotinamide in recent-onset IDDM (the IMDIAB III study). Diabetologia. 1995;38:848-852.
122. Polo V, Saibene A, Pontiroli AE. Nicotinamide improves insulin secretion and metabolic control in lean type 2 diabetic patients with secondary failure to sulphonylureas. Acta Diabetol. 1998;35:61-64.
123. Jonas WB, Rapoza CP, Blair WF. The effect of niacinamide on osteoarthritis: a pilot study. Inflamm Res. 1996;45:330-334.
124. Hoffer A. The vitamin paradigm wars. Townsend Letters for Doctors and Patients 1996;June:56-60.
125. Hoffer A. Safety, side effects and relative lack of toxicity of nicotinic acid and nicotinamide. Schizophrenia 1969;1:78-87.
126. Goodman AG, et al. Goodman and Gilman's The Pharmacological Basis of Therapeutics. Eighth Edition, New York, Pergamon Press, 1990.
127. Murray M, Pizzorno J. Encyclopedia of Natural Medicine. Second Edition. Rocklin, CA, Prima Health, 1998.
128. Anand JC. Osteoarthritis and pantothenic acid. Journal of the College of General Practice 5:136-7, 1963.
129. "Vitamin B6." BBC News. 8 June 2004. 7 Oct. 2005 <http://searchenginewatch.com/searchday/article.php/3398511>.
130. Leklem JE. Vitamin B6. In: Shils ME, Olson JA, Shike M, Ross AC, ed. Modern Nutrition in Health and Disease. 9th ed. Baltimore: Williams and Wilkins, 1999: 413-421.
131. U.S. Department of Agriculture, Agricultural Research Service,1999. USDA Nutrient Database for Standard Reference, Release 13. Nutrient Data Lab Home Page, http://www.nal.usda.gov/fnic/foodcomp
132. Malouf M, Grimley EJ, Areosa SA. Folic acid with or without vitamin B12 for cognition and dementia. Cochrane Database Syst Rev. 2003;(4):CD004514.
133. Deijen JB, van der Beek EJ, Orlebeke JF, van den BH. Vitamin B-6 supplementation in elderly men: effects on mood, memory, performance and mental effort. Psychopharmacology (Berl). 1992;109(4):489-96.