- Bacopa Monniera
- Folic Acid
- Ginkgo Biloba
- Gotu Kola
- Huperzine A
- N-Acetyl Tyrosine
- Panax Ginseng
- R-Alpha Lipoic Acid
- Rhodiola Rosea
- Vitamin B1 Thiamine
- Vitamin B2 Riboflavin
- Vitamin B3 Niacinamide
- Vitamin B5 Pantothenic Acid
- Vitamin B6 Pyridoxine
Short-term and long-term memory
Enhance concentration and reaction time
Protect brain from free radicals
Reduce stress and anxiety levels
Increase blood flow and oxygen to the brain
Support growth of brain cells
Some participants who use acetyl-l-carnitine have reported being more mentally sharp, focused, alert and in a better mood.
Studies have shown acetyl-l-carnitine to...
help facilitate regeneration of nerves. 1
reduce the formation of a cell-clogging pigment called lipfuscin. 2
work synergistically with CoQ10 and alpha lipoic acid creating an anti-aging effect which helps to maintain mitochondria function. 3,4
provide significant improvements in cognitive function for people with mild cognitive impairment after 45 days of use. 5
provide significant improvement in memory, mood, and response to stress for elderly people after 90 days of use and the effects lasted at least 30 days after the trial had ended. 6
Users of bacopa monniera have reported increased relaxation, academic performance, short term and long term memory, and concentration in stressful situations.
The use of bacopa for memory enhancement can be traced back over 2000 years ago when bacopa was cited for its memory enhancing attributes in the Indian Vedic texts Athar-Ved Samhita in 800 B.C.. 11
A 1969 study showed that animals who were given bacopa had increased learning abilities and memory enhancement. 12
In 1996, Scientists from India's Central Drug Research Institute reported that bacopa reduces the time to learn a specific task from ten days to six days (a 40% reduction in time). 13
One study reported that when bacopa was given to a group of children, the children improved their speed and accuracy on maze problems. 14
Bacopa was reported to improve IQ scores in 10 to 13 year olds of average intelligence during a 9 month period of use. 15
Findings suggest that Bacopa may improve higher order cognitive processes such as learning and memory. 16
Bioperine® is a patented extract obtained from black pepper fruits of southern India.
Bioperine® was clinically tested in the USA and has been found to significantly enhance the absorption of many nutrients. 17
Many nutritionists are beginning to agree that better nutrition relies not just on what people eat, but how well they absorb what they eat.
Some studies show that Bioperine® can increase absorption of CoQ10 by approximately 30%, while other trials show a 2000% absorption increase (BrainAlert contains CoQ10). 18
Bioperine has been used with the following ingredients to increase absorption:
herbal extracts (ashwagandha, capsaicin, curcumin, boswellia serrata, and ginkgo biloba), amino acids (isoleucine, leucine, lysine, methionine, phenylalanine, threonine, tryptophan, and valine), water-soluble vitamins (folic acid, niacin, vitamin B1, B2, B6, B12, and C), fat-soluble vitamins (vitamin A, D, E, and K) and minerals (calcium, chromium copper, iodine, iron, magnesium, manganese, potassium, vanadium, and zinc).
A study examining 349 patients, 64 years and older from 6 regions in Italy who had memory complaints, showed that participants who received Citicoline had significantly higher memory scores, as shown on the Mini–Mental State Examination (MMSE), with treatment of up to 9 months compared with their counterparts who did not receive Citicholine.
Supports increased levels of nuerotransmitters, such as dopamine and norepinephrine.
Many people supplement their diet with CoQ10 to increase energy, to support immune system function, and for its antioxidant properties.
CoQ10 is found naturally in fish and animal meats.
CoQ10 is found naturally in the body, with the highest concentrations in the kidney, liver, and heart.
CoQ10 levels begin to decline after approximately 30 years of age. 27
DMAE was used to help ADD children in the 1980's, with studies showing improvement in memory, concentration, and the ability to focus. 28,29
Some individuals taking DMAE as a supplement report a noticeable boost in concentration, memory, improved focus, sleep pattern, and mental clarity.
Some participants who take DMAE report falling asleep easier, have more lucid dreams, less fatigue in the day, deeper sleep, and needing less sleep at night. 30
A study consisting of 83 boys and 25 girls found improved scholastic ability, lengthened attention span, decreased hyperactivity, and decreased irritability among two-thirds of the boys and three-fourths of the girls. 31
Folic acid is also known as folate and vitamin B9.
Folic acid is one of eight water-soluble complex B vitamins that are essential in the breakdown of fats and proteins.
Folic acid is also known to play an important role in mental and emotional health.
Folic acid aids in the production of DNA and RNA.
Studies have shown folic acid to promote memory retention. 34
Ginkgo biloba is an herbal extract from the leaves of the ginkgo tree (the world's oldest living tree) and has been used therapeutically in China for thousands of years.
For the past five years ginkgo biloba has been the top-selling herbal dietary supplement in the United States. 35
Studies have shown Ginkgo Biloba to...
contribute to the improvement of cognitive performance and function. 36,39
help improve memory. 37
Pooled results from 33 studies show that the recommended dose of ginkgo biloba (<200mg/day) can significantly improve emotional health and mood, cognition, and daily activities. 38
For thousands of years gotu kola has been used as a medicinal herb in China, India, and Indonesia.
Gotu kola is a tender plant with long stems and small grey-green leaves, and is typically found in high marshy areas of South Africa, Madagascar, India, and Pakistan.
Gotu kola is considered to be a "miracle elixir of life" in China.
Traditionally, gotu kola has been used to treat anxiety (1)(2), though it is also associated with learning and recollection enhancement.
Researchers have tested the herb in relation to startle response, since evidence suggests that easy startling is associated with anxiety. 40
By measuring eye blinks in response to sudden loud noises, Gotu Kola significantly reduced startle response.41
A 1992 study claimed that gotu kola improved the cognitive abilities of rats. 42
Huperzine A is an extract from a club moss (Huperzia Serrata) and has been used for centuries in China.
The primary purpose of huperzine A is to prevent the breakdown of acetylcholine. Acetylcholine is vital to the nervous system for transmitting information between cells. 43
Studies have shown Huperzine A to...
promote memory and learning. 44
be more effective and selective than tacrine, a pharmaceutical drug, at inhibiting cholinesterase. 45-60
help protect nerve cells from damage. 61-64
"Huperzine A appears to bind more tightly and specifically to acetylcholinesterase than the other acetylcholinesterase inhibitors. It is as if this natural substance were ingeniously designed to fit into the exact spot in acetylcholinesterase where it will do the most good." Prof. Joel Sussman
Carnosine significantly increases the endurance, contractility, and minimizes lactic acid build up of muscles.
Carnosine is a metal chelator, meaning it helps remove metals from the body.
Carnosine levels decrease with age. From age 10 to 70, muscle levels decline 63%, which may be linked to the decrease of carnosine levels. 19
Research has shown that carnosine rejuvenates cells as they approach advanced ages. 20
A 1999 Russian study showed that carnosine extended the life span of treated mice by an average of 20% compared to non-treated mice. The mice were twice as likely to reach old age as untreated mice. 21,22
Methylcobalamin is a coenzyme form of vitamin B12 (cyanocobalamin).
Vitamin B12 helps methylation reactions and immune system regulation.
Science indicates that Methylcobalamin has some effects not shared by regular vitamin B12.
Studies have shown Methylcobalamin to...
protect brain cells against glutamate toxicity.65
decrease amount of time people sleep while improving the quality of sleep so that the individuals awake feeling more refreshed.67
potentially help regenerate nerves. 68
help regenerate damaged brain axons.69
N-Acetyl Tyrosine is an acetylated derivative of the essential amino acid L-Tyrosine. Acetylation helps to improve the metabolic effect of L-Tyrosine.
L-Tyrosine is the precursor of several neurotransmitters in the brain including epinephrine, norepinephrine, and dopamine.
Studies have shown Tyrosine to...
Improve learning and alertness.72
Reduce mental and physical fatigue. 73
Panax Ginseng is one of the most popular and highly researched forms of ginseng.
The root of the ginseng plant has been prescribed in China , Korea , and Japan for hundreds of years to improve energy levels.
The benefits of ginseng have been written about as far back as the Sui Dynasty of China (580 - 601 A.D.).
Ginseng is one of the most popular selling herbs around the world.
Studies have shown panax ginseng to...
improve physical and mental performance.74,75
increase resistance to stress factors.74,75
improve reactions and abstract thinking. 76
improve attention, processing, auditory reaction time, mental health, and social functioning.77,78
improve secondary memory performance, speed of memory tasks, and accuracy of attention tasks.79
improve immune system function. 80,81
A comparative, randomized, and double-blind government study indicated that ginseng is "a promising dietary supplement" in regards to an increase in quality of life. 83
Double-blind studies have found this ingredient to help improve mental function in people with age-related memory loss.
It has also been proposed for enhancing mental function in young people.
Alpha-Lipoic Acid (ALA) may be a more potent antioxidant than classic antioxidants, such as Vitamins E and C.
ALA was first isolated in 1953, and is sometimes referred to as "universal antioxidant" because it is soluble in both fat and water. 84
Studies have shown Alpha-Lipoic acid to...
Regenerate other antioxidants back to their active states, including CoQ10, and vitamins C and E.85-87
Greatly improve activity, energy levels, and cognitive functions of old rats when combined with acetyl-l-carnitine. 88-90 (BrainAlert contains acetyl-l-carnitine)
Rhodiola rosea is a perennial plant that grows in the arctic areas of Europe and Russia
Rhodiola rosea has long been used in the traditional medicines of Russia and Scandinavia 91 and has been extensively researched in Russia and China for the last several decades.
More than 170 studies have been published on Rhodiola Rosea since the 1960's.
A 2004 study showed rhodiola rosea to improve endurance-exercise capacity in young and healthy individuals. 92
A 2003 study showed rhodiola rosea to provide a definite decrease in mental fatigue. 93
Studies have shown rhodiola rosea to...
stimulate the body, decrease fatigue, and decrease stress.94-100
significantly decrease the percent of errors made in a proof-reading test. 101,102
increase intellectual capacity more than siberian ginseng (14) 103
In 1970, a Russian study claimed that rhodiola rosea supplementation increased the quality and amount of work for 27 healthy students, physicians, and scientists.104
A 20 day study of 60 Indian medical students in 2000 showed that while studying for final exams, those who took a Rhodiola Rosea extract yielded significant improvements in their physical fitness, general well-being, and final exam grades.
A double-blind placebo-controlled study of 60 high school students in 2000, showed that Rhodiola Rosea supplementation increased work capacity, coordination, and feelings of well-being, while simultaneously decreasing fatigue and stress. 105
Trimethylglycine is also known as betaine and its functions are similar to folic acid and vitamin B12. 106,107
Trimethylglycine was originally discovered in the 1950's to be beneficial to the heart, but soon after some users indicated improvements to their energy, alertness, and mood.
Vinpocetine is a semi-synthetic derivative of a periwinkle plant extract.
Vinpocetine increases blood circulation and metabolism in the brain.
Over 100 clinical studies have revealed vinpocetine to be safe and effective. 116,117
Studies have shown vinpocetine to...
significantly improve attention, concentration, and memory. 115
help increase cerebral blood flow. 114 Due to this increase of blood flow to the brain, vinpocetine works synergistically with other cognitive agents.
help reduce platelet aggregation while improving deformation resistance of red blood cells. 118
In 1926 vitamin B1, also known as thiamine, was the first vitamin to be isolated in pure form.
Thiamine is vital to the metabolism of carbohydrates and amino acids.
Deficiencies in B vitamins can lead to fatigue and poor mental functioning.
Over recent years there has been a decrease in B vitamins intake due to the increased consumption of refined foods.
Studies have shown Vitamin B1 to...
provide cognitive benefits, including faster reaction times, clear-headedness, and increased concentration.112,113
improve mood and energy. 113
Vitamin B2 is found in meats, eggs, nuts, milk, and green leafy vegetables.
Vitamin B2 is also called riboflavin and is one of eight water soluble B vitamins.
Some authorities clam that vitamin B2 deficiency is the most common nutrient deficiency in the United States.
Vitamin B2 plays a role in enzyme function, amino acid synthesis, and energy production.
Niacin was discovered in 1911.
Niacinamide and niacin are both vitamin B3, but niacinamide has different pharmological activities than niacin.
Niacinamide is easily absorbed by the gastrointestinal tract.
Niacinamide works in conjunction with vitamin B1 and vitamin B2 to convert carbohydrates into energy.
Studies have shown niacinamide to produce an anti-anxiety effect. 124
Pantothenic acid was first identified in 1933. 126
High concentrations of pantotheic acid can be found in salmon, brewer's yeast, soybeans, duck, broccoli, and corn.
Pantothenic acid works together with vitamins B1, B2, and B3 to create energy in the body.
Pantothenic acid supports adrenal function in high stress situations.127
Pantothenic acid is easily absorbed by the gastrointestinal tract.
Some users of pantothenic acid report improved alertness, energy, and mood.
Pyridoxine was first discovered in 1934.
Over a million people supplement their diet with pyridoxine to help alleviate stress and increase energy. 129
Pyridoxine is found in some cereals, beans, meats, fruits, and vegetables. 130,131
A study involving 76 elderly males showed pyridoxine to help improve long-term memory. 133
Pyridoxine supports the manufacturing of enzymes, hormones, red blood cells, and neurotransmitters.
Pyridoxine is needed in order for the human body to produce serotonin. 130 Serotonin is a neurotransmitter that controls appetite, sleep patterns, and mood.
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